Gebreyes' professional expertise lies in the area of global health and infectious zoonotic diseases. His team conducts research on globally important zoonotic and foodborne diseases of public health significance witha major emphasis on antimicrobial resistance. In the One Health Ethiopia project, he directs the overall program as well as teaches molecular epidemiology of infectious diseases. In addition, he is the core team leader for rabies prevention and control project and co-PI on rapid diagnostics of bovine TB project activities.